- Friday, September 10, 2021
- 1:30 PM–2:30 PM
- Science Building 010
Join the students of BIO295 ("Biology Seminar") as we welcome speakers from a variety of locations with a great array of experiences to our campus. Join us as we learn about their unique backgrounds and work within the field of Biology.
"Summer Research on Duchenne Muscular Dystrophy"
Guest Speaker: Emmanuella Akeampong - Student, Calvin University
Friday, Sept. 10th, 2021
1:30p - 2:20p
*Science Building (SB) 010 (tentative location- any changes to location will be posted)
Duchenne Muscular Dystrophy (DMD) is a rare, X-linked recessive genetic disorder which is caused by null mutations in dystrophin and affects the structure and function of striated muscle of affected patients. Clinically, this condition is characterized by muscle degeneration, progressive symmetrical muscular weakness, cardiomyopathy and high levels of serum creatine kinase which is hypothesized to be due to loss of sarcolemma integrity. In other types of cardiac muscle injury such as ischemia, muscle membranes are compromised by a form of iron-dependent cell death called ferroptosis. Therefore, the aim of this summer project was to determine if activation of ferroptosis contributes to loss of sarcolemma integrity in DMD and to test the effectiveness of Ferrostatin-1, a ferroptosis inhibitor, to protect muscle injury in dystrophin-deficient mdx mice, the mouse model of DMD.
Any questions? Please contact Erika Purcell-Williams (eap2@calvin.edu) for further assistance.
Location details
Located on bottom floor of Science Building
